Clustering: Niches & Domains¶
Spatial clustering for tissue architecture analysis.
Overview¶
SpatialCore provides methods for characterizing tissue microenvironments at two levels:
| Concept | Definition | Key Property |
|---|---|---|
| Neighborhood | Immediate spatial vicinity of a cell (k-NN or radius) | Local context (input for niche/domain) |
| Niche | Cellular microenvironment archetype defined by cell-type composition | Compositional (location-independent) |
| Domain | Spatially contiguous tissue region | Spatial (partitions tissue) |
See Terminology for detailed definitions with literature citations.
Methods¶
| Method | Description |
|---|---|
| Neighborhood & Niche Analysis | Clustering neighborhoods by cell-type composition |
| Domain Detection | Identifying spatially contiguous tissue regions |